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  1. RNA-binding protein Translocated in LipoSarcoma/FUsed Sarcoma (TLS/FUS) is one of causative genes for familial amyotrophic lateral sclerosis (ALS). We previously identified that TLS was associated with protein...

    Authors: Kenta Fujimoto and Riki Kurokawa
    Citation: Cell & Bioscience 2014 4:77
    Content type: Research Published on:

  2. Golgi protein-73 (GP73) is a Golgi transmembrane glycoprotein elevated in numerous liver diseases. Clinically, GP73 is strongly elevated in the serum of HCC patients and is thus regarded as a novel potential b...

    Authors: Fang Wang, Qi Long, Yu Gong, Longbo Hu, Hong Zhang, Peter Oettgen and Tao Peng
    Citation: Cell & Bioscience 2014 4:76
    Content type: Research Published on:

  4. X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell via a random process. Skewed XCI is relevant to many diseases, but...

    Authors: Yumei Luo, Jieliang Li, Detu Zhu, Yong Fan, Shaoying Li and Xiaofang Sun
    Citation: Cell & Bioscience 2014 4:74
    Content type: Research Published on:

  6. IL-25 is emerging as a key regulator of inflammation in the intestinal mucosa because of its ability to promote type 2 while suppressing Th1 and Th17 responses. Several previous studies reported inconsistent r...

    Authors: An-Jiang Wang, Allen Smith, Yanfei Li, Joseph F Urban Jr, Thirumalai R Ramalingam, Thomas A Wynn, Nonghua Lu, Terez Shea-Donohue, Zhonghan Yang and Aiping Zhao
    Citation: Cell & Bioscience 2014 4:72
    Content type: Research Published on:

  7. Ceramides are a class of sphingolipids that form the structural component of the cell membrane and also act as second messengers in cell signaling pathways. Emerging results suggest that ceramide induces growt...

    Authors: Zhe Liu, Yichao Xia, Bo Li, Hui Xu, Chenxing Wang, Ying Liu, Yi Li, Chunjie Li, Ning Gao and Longjiang Li
    Citation: Cell & Bioscience 2014 4:71
    Content type: Research Published on:

  8. Chemical crosslinking is the most straightforward method to produce bispecific antibodies (BsAb) for arming ex vivo activated cytotoxic T lymphocytes. However, heterogeneous polymers are produced by chemical cros...

    Authors: Qingzhong He, Haisong Zhang, Youzhao Wang, Hong Hoi Ting, Wenhua Yu, Xuetao Cao and Wei Ge
    Citation: Cell & Bioscience 2014 4:70
    Content type: Research Published on:

  9. Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped...

    Authors: Victoria R Zellmer and Siyuan Zhang
    Citation: Cell & Bioscience 2014 4:69
    Content type: Review Published on:

  10. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is a unique, in silico-designed compound with possible anticancer properties, which were identified in our laboratory. This compound is capable of interf...

    Authors: Elize Wolmarans, Katherine Sippel, Robert McKenna and Annie Joubert
    Citation: Cell & Bioscience 2014 4:68
    Content type: Research Published on:

  11. Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development,...

    Authors: Ying-Ju Lin, Jeng-Sheng Chang, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Wen-Kuei Chien, Jin-Hua Chen, Jer-Yuarn Wu, Chien-Hsiun Chen, Li-Ching Chang, Cheng-Wen Lin, Tsung-Jung Ho and Fuu-Jen Tsai
    Citation: Cell & Bioscience 2014 4:67
    Content type: Research Published on:

  14. Mounting evidence supports the role of hydrogen peroxide (H2O2) in physiological signaling as well as pathological conditions. However, the subtleties of peroxide-mediated signaling are not well understood, in pa...

    Authors: Hengchang Guo, Hossein Aleyasin, Bryan C Dickinson, Renée E Haskew-Layton and Rajiv R Ratan
    Citation: Cell & Bioscience 2014 4:64
    Content type: Review Published on:

  15. Drosophila melanogaster has been a classic model organism for the studies of genetics. More than 15,000 Drosophila genes have been annotated since the entire genome was sequenced; however, many of them still lack...

    Authors: Shih-Ching Lin, Yu-Yun Chang and Chih-Chiang Chan
    Citation: Cell & Bioscience 2014 4:63
    Content type: Review Published on:

  16. MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. MiR-20b has been reported to participate in breast cancer tumorigenic progression, however, ...

    Authors: Weidong Zhou, Guixiu Shi, Qiuyan Zhang, Qiuwan Wu, Boan Li and Zhiming Zhang
    Citation: Cell & Bioscience 2014 4:62
    Content type: Research Published on:

  17. The transactivator of transcription (Tat) protein of human immunodeficiency virus type 1 (HIV-1) is known to undergo ubiquitination. However, the roles of ubiquitination in regulating Tat stability and activit...

    Authors: Linlin Zhang, Juan Qin, Yuanyuan Li, Jian Wang, Qianqian He, Jun Zhou, Min Liu and Dengwen Li
    Citation: Cell & Bioscience 2014 4:61
    Content type: Research Published on:

  18. The adapter proteins Appl1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine domain, and leucine zipper motif 1) and Appl2 are highly homologous and involved in several signaling pathways...

    Authors: Liufeng Mao, Wanhua Lin, Tao Nie, Xiaoyan Hui, Xuefei Gao, Kuai Li, Mengxiao Ding, Xiaofeng Tang, Peng Li, Yu Wang, Aimin Xu, Pentao Liu and Donghai Wu
    Citation: Cell & Bioscience 2014 4:60
    Content type: Research Published on:

  19. Akt regulates critical cellular processes including cell survival and proliferation, glucose metabolism, cell migration, cancer progression and metastasis through phosphorylation of a variety of downstream tar...

    Authors: Chia-Hsin Chan, Ukhyun Jo, Abraham Kohrman, Abdol Hossein Rezaeian, Ping-Chieh Chou, Christopher Logothetis and Hui-Kuan Lin
    Citation: Cell & Bioscience 2014 4:59
    Content type: Review Published on:

  22. Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalli...

    Authors: Danielle E Read, Ananya Gupta, Yury Ladilov, Afshin Samali and Sanjeev Gupta
    Citation: Cell & Bioscience 2014 4:56
    Content type: Research Published on:

  23. Herpes simplex virus (HSV) type 1 has a 152 kb double-stranded DNA genome that may encode more than 80 gene products, many of which remain uncharacterized. The HSV-1 triplex is a complex of three protein subun...

    Authors: You Li, Dongwei Mao, Guoda Ma, Lili Cui, Hua Tao, Haihong Zhou, Wandong Liang, Bin Zhao and Keshen Li
    Citation: Cell & Bioscience 2014 4:55
    Content type: Short report Published on:

  25. Both transcriptional factor Ets-1 and integrin αvβ6 play an important role in the development and progression of cancer. The aim of our study was to investigate the expression of Integrin αvβ6 and Ets-1, two p...

    Authors: Cheng Peng, Huijie Gao, Zhengchuan Niu, Ben Wang, Zhen Tan, Weibo Niu, Enyu Liu, Jiayong Wang, Jiuzheng Sun, Muhammad Shahbaz, Michael Agrez and Jun Niu
    Citation: Cell & Bioscience 2014 4:53
    Content type: Research Published on:

  26. Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and also the epimerization of DHNP to 7,8-dihydromonapterin. Previously, we determined the...

    Authors: Jaroslaw Blaszczyk, Zhenwei Lu, Yue Li, Honggao Yan and Xinhua Ji
    Citation: Cell & Bioscience 2014 4:52
    Content type: Research Published on:

  28. Ductular reactions (DRs) are well documented in many acute and chronic liver disease. The DRs are thought to be the transit amplifying cells deriving from activation of the stem/progenitor cell compartments of...

    Authors: Fei Ye, Ying-Ying Jing, Shi-Wei Guo, Guo-Feng Yu, Qing-Min Fan, Fang-Fang Qu, Lu Gao, Yang Yang, Dong Wu, Yan Meng, Feng-Hai Yu and Li-Xin Wei
    Citation: Cell & Bioscience 2014 4:50
    Content type: Research Published on:

  29. Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression is correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery...

    Authors: Tingting Fan, Changsong Zhang, Ming Zong, Qiudong Zhao, Xue Yang, Chong Hao, Hui Zhang, Shanshan Yu, Jinhu Guo, Ruhan Gong, Shasha Fan, Lixin Wei and Lieying Fan
    Citation: Cell & Bioscience 2014 4:49
    Content type: Research Published on:

  30. Sirtuin1 (SIRT1) is an NAD+-dependent type III histone deacetylase (HDAC). This research investigated the prevalence of SIRT1 protein expression and its prognostic influence with the aim of validating its potenti...

    Authors: Guan-qing Chen, Hui Tian, Wei-ming Yue, Lin Li, Shu-hai Li, Lei Qi, Cun Gao, Li-bo Si, Ming Lu and Fei Feng
    Citation: Cell & Bioscience 2014 4:48
    Content type: Research Published on:

  31. Cholestasis is characterized by an abnormal accumulation of bile acids and causes hepatocellular injury. Recent studies show that autophagy is involved in the pathophysiology of many liver diseases. The potent...

    Authors: Lu Gao, Gang Lv, Xianling Guo, Yingying Jing, Zhipeng Han, Shanshan Zhang, Kai Sun, Rong Li, Yang Yang and Lixin Wei
    Citation: Cell & Bioscience 2014 4:47
    Content type: Research Published on:

  33. Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell. Genetic modifications include loss or amplification of DNA, loss of ...

    Authors: Eva Baxter, Karolina Windloch, Frank Gannon and Jason S Lee
    Citation: Cell & Bioscience 2014 4:45
    Content type: Review Published on:

  34. Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan ge...

    Authors: Hsuan Liu, Chung-Pei Ma, Yi-Tung Chen, Scott C Schuyler, Kai-Ping Chang and Bertrand Chin-Ming Tan
    Citation: Cell & Bioscience 2014 4:44
    Content type: Review Published on:

  37. Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human...

    Authors: Kun-Shiang Chen, Ming-Der Shi, Chi-Sheng Chien and Yuan-Wei Shih
    Citation: Cell & Bioscience 2014 4:41
    Content type: Research Published on:

  38. The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...

    Authors: Ying-Ju Lin, Chia-Yen Chen, Kuan-Teh Jeang, Xiang Liu, Jen-Hsien Wang, Chien-Hui Hung, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Cheng-Wen Lin, Mao-Wang Ho, Wen-Kuei Chien, Jin-Hua Chen, Tsung-Jung Ho and Fuu-Jen Tsai
    Citation: Cell & Bioscience 2014 4:40
    Content type: Research Published on:

  39. Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is...

    Authors: Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee, Tin Oo Khor, Zheng-Yuan Su, Limin Shu, Yaoping Lu, Allan H Conney and Ah-Ng Tony Kong
    Citation: Cell & Bioscience 2014 4:39
    Content type: Research Published on:

  40. Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It...

    Authors: Xuan Yao, Sarina Hou, Duo Zhang, Hongfeng Xia, Yu-Cheng Wang, Jingjing Jiang, Huiyong Yin and Hao Ying
    Citation: Cell & Bioscience 2014 4:38
    Content type: Research Published on:

  42. Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example,...

    Authors: Paolo Swuec and Alessandro Costa
    Citation: Cell & Bioscience 2014 4:36
    Content type: Review Published on:

  43. miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profil...

    Authors: Bo Deng, Julian Molina, Marie C Aubry, Zhifu Sun, Liang Wang, Bruce W Eckloff, George Vasmatzis, Ming You, Eric D Wieben, Jin Jen, Dennis A Wigle and Ping Yang
    Citation: Cell & Bioscience 2014 4:35
    Content type: Research Published on:

  44. A team of scientists led by Professor DW Pang at Wuhan University have developed a new class of fluorescence probes based on bacterial cells. These microbial factories manufacture semiconductor nanocrystals in...

    Authors: Jing Shang and Xiaohu Gao
    Citation: Cell & Bioscience 2014 4:34
    Content type: Commentary Published on:

  45. The potential biodiesel plant castor bean (Ricinus communis) has been in the limelight for bioenergy research due to the availability of its genome which raises the bar for genome-wide studies claiming advances t...

    Authors: Umashankar Chandrasekaran, Wei Xu and Aizhong Liu
    Citation: Cell & Bioscience 2014 4:33
    Content type: Research Published on:

  48. Double-stranded DNA translocation is ubiquitous in living systems. Cell mitosis, bacterial binary fission, DNA replication or repair, homologous recombination, Holliday junction resolution, viral genome packag...

    Authors: Gian Marco De-Donatis, Zhengyi Zhao, Shaoying Wang, Lisa P Huang, Chad Schwartz, Oleg V Tsodikov, Hui Zhang, Farzin Haque and Peixuan Guo
    Citation: Cell & Bioscience 2014 4:30
    Content type: Research Published on:

  50. Non-alcoholic fatty liver disease, one of the most common liver diseases, has obtained increasing attention. Palmitate (PA)-induced liver injury is considered a risk factor for the development of non-alcoholic...

    Authors: Ning Cai, Xue Zhao, Yingying Jing, Kai Sun, Shufan Jiao, Xiaojing Chen, Haozheng Yang, Yan Zhou and Lixin Wei
    Citation: Cell & Bioscience 2014 4:28
    Content type: Research Published on:
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Cell & Bioscience

ISSN: 2045-3701

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