Table 1 Univariate and multivariate analyses of prognosis in hepatocellular carcinoma (cohort 2, n = 323)
From: FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion
Variable | Time to recurrence | Overall survival | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Univariate analysis | ||||
Age, year (≤ 50 versus > 50) | 0.977(0.726–1.315) | 0.879 | 1.207(0.889–1.640) | 0.228 |
Sex (female versus male) | 1.863(1.143–3.036) | 0.013 | 1.757(1.049–2.942) | 0.032 |
HBsAg (negative versus positive) | 0.978(0.664–1.442) | 0.912 | 1.002(0.670–1.498) | 0.993 |
AFP, ng/ml (≤ 20 versus > 20) | 1.155(0.835–1.597) | 0.385 | 1.548(1.083–2.211) | 0.016 |
GGT, U/L (≤ 54 versus > 54) | 1.329(0.978–1.805) | 0.069 | 1.737(1.253–2.409) | 0.001 |
Liver cirrhosis (no versus yes) | 1.160(0.712–1.889) | 0.552 | 1.362(0.801–2.315) | 0.254 |
Tumor size, cm (≤ 5 versus > 5) | 1.817(1.346–2.452) | 0.000 | 2.482(1.806–3.412) | 0.000 |
Tumor number (single versus multiple) | 1.362(0.907–2.044) | 0.136 | 1.517(1.025–2.243) | 0.037 |
Microvascular invasion (no versus yes) | 1.915(1.420–2.583) | 0.000 | 2.479(1.815–3.388) | 0.000 |
Tumor encapsulation (complete versus none) | 1.679(1.246–2.263) | 0.001 | 1.715(1.260–2.336) | 0.001 |
Tumor differentiation (I + II versus III + IV) | 1.238(0.870–1.753) | 0.236 | 1.581(1.119–2.233) | 0.009 |
TNM stage (I versus II + III) | 1.226(0.912–1.650) | 0.178 | 1.563(1.149–2.125) | 0.004 |
FTO (low versus high) | 0.667(0.494-0.900) | 0.008 | 0.624(0.457–0.852) | 0.003 |
Multivariate analysis | ||||
Sex (female versus male) | 1.740(1.066–2.842) | 0.027 | 1.421(0.837–2.414) | 0.193 |
AFP, ng/ml (≤ 20 versus > 20) | NA | NA | 1.218(0.838–1.770) | 0.301 |
GGT, U/L (≤ 54 versus > 54) | NA | NA | 1.466(1.041–2.065) | 0.029 |
Tumor size, cm (≤ 5 versus > 5) | 1.629(1.198–2.216) | 0.002 | 1.964(1.400-2.754) | 0.000 |
Tumor number (single versus multiple) | NA | NA | 1.309 (0.870–1.970) | 0.196 |
Microvascular invasion (no versus yes) | 1.582(1.157–2.162) | 0.004 | 2.062(1.482–2.869) | 0.000 |
Tumor encapsulation (complete versus none) | 1.590(1.171–2.158) | 0.003 | 1.656(1.202–2.281) | 0.002 |
Tumor differentiation (I -II versus III + IV) | NA | NA | 1.865(1.311–2.655) | 0.001 |
TNM stage (I versus II + III) | NA | NA | NA | NA |
FTO (low versus high) | 0.774(0.567–1.056) | 0.106 | 0.695(0.504–0.957) | 0.026 |