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Fig. 4 | Cell & Bioscience

Fig. 4

From: The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation

Fig. 4

RNA-seq reveals the involvement of key genes for B-cell development. A. Dot plot representation of the RNA‐seq results. The red dots represent significantly upregulated genes in Dido1∆E16 pre-B cells, the green dots represent significantly downregulated genes (|log2 FC|≥ 1 and FDR < 0.01). B. GSEA enrichment graphs of genesets relative to PRC2 activity and differentially expressed genes in pre-B cells. The RNA-seq expression data are ranked according to fold change in the transcription levels in pre-B Dido1∆E16 cells, compared to pre-B WT cells. A maximal correlation was observed between the expression of altered genes in pre-B Dido1∆E16 cells and genes identified by ChIPseq as targets of PRC2 components JARID2 (p < 0.001; FDR = 0.213) and SUZ12 (p < 0.001: FDR = 0.217). C. STRING analysis and clustering of differentially expressed genes between Dido1∆16 and WT LSK cells. It shows that differentially expressed genes are involved in known and predicted protein–protein interactions. Interaction score > 0.4

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