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Fig. 1 | Cell & Bioscience

Fig. 1

From: Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models

Fig. 1

Behavior profiling in wild-type mice with neuronal CD47 overexpression. (A) Time spent in the right and left chambers during the habituation phase. (B) A representative trajectory plot of control and neuronal CD47 overexpression mice in the three-chamber test. (C) Time spent in the right and left chambers during the social phase. (D) The discrimination ratio was calculated using the formula: (time in social chamber - time in nonsocial chamber) / total time. (n = 14 for control, n = 11 for CD47 overexpression mice). (E) Time spent in the left and right chambers during the social novelty phase. (F) The duration of self-grooming behavior displayed by control and CD47 overexpression mice over a 10-minute period. (n = 14 for control, n = 11 for CD47 overexpression mice). (G) A representative image of buried marbles from the marble burying test. (H) The number of marbles buried by control and CD47 overexpression mice over a 30-minute period. (n = 14 for control, n = 11 for CD47 overexpression mice). (I) A representative trajectory plot of control and neuronal CD47 overexpression mice in the open field test. (J-M) Time (J), number of entries (K), and distance traveled (L) in the inner zones of the open field arena. (M) Total distance traveled in the inner and outer zones of the open field arena (n = 8 for control, n = 20 for CD47 overexpression mice). (N) A representative trajectory plot of control and neuronal CD47 overexpression mice in the elevated plus maze. (O-R) Time (O), number of entries (P), and distance traveled (Q) in the open arm of the elevated plus maze. (R) Total distance traveled in the open and closed arms of the elevated plus maze (n = 8 for control, n = 20 for CD47 overexpression mice). (S) A representative trajectory plot of control and neuronal CD47 overexpression mice in the Morris water maze. (T-U) Number of platform crossings (T) and time traveled (U) in the target quadrants of the Morris water maze (n = 8 for control, n = 20 for CD47 overexpression mice). Data are presented as the mean ± SEM. *P ≤ 0.05, **P ≤ 0.01

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Cell & Bioscience

ISSN: 2045-3701

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