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Fig. 6 | Cell & Bioscience

Fig. 6

From: Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation

Fig. 6

ER stress enhances NLRP3 inflammasome activation in clusterin-KO primary HCs and KCs (A, B) Representative real-time RT-PCR analysis of NLRP3, IL1β, TNFα, and IL6 mRNA levels in clusterin-KO primary KCs (A) and HCs (B) treated with Tg (1 μM, 24 h). *p < 0.05, **p < 0.01, ***p < 0.001. (C) ELISA of IL1β levels in clusterin-KO primary HCs and KCs treated with Tg (1 μM, 24 h). *p < 0.05, ***p < 0.001. (D) Representative western blot analysis of NLRP3 and IL1β protein expression in lysates of clusterin-KO primary HCs and KCs treated with Tg

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Cell & Bioscience

ISSN: 2045-3701

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