Fig. 4

NLRP3 inflammasome activation in clusterin-KO mice fed a DDC diet. (A, B) Immunohistochemical analysis of NLRP3 (A) and IL1β (B) expression in WT and clusterin-KO mice fed a DDC diet for 20 days. Data in the bar graph are means ± SEM. ***p < 0.001. Scale bars indicate 100 μm. (C) Representative western blot analysis of NLRP3 inflammasome markers in WT and clusterin-KO mice fed a DDC diet for 20 days. *p < 0.05, **p < 0.01, ***p < 0.001