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Table 2 Alterations in presynaptic excitatory and inhibitory neurotransmission in depression

From: Altered synaptic homeostasis: a key factor in the pathophysiology of depression

Synaptic transmission

Animal Model

Brain region

Frequency change

References

sEPSC

RS rats

DRN

Increase

[109]

 

HFD + CSDS mice

mPFC

Decrease

[110]

 

CVS mice

PVN

Increase

[111]

 

CIS mice

mPFC

Decrease

[112]

mEPSC

CUS mice

mPFC PrL D1-PYR/ D2-PYR

Increase/ Decrease

[113]

 

ELS mice

mPFC IL

Decrease

[114]

 

LH rats

vlPAG

Decrease

[103]

 

CUS rats

mPFC

Decrease

[115]

 

LANs rats

vlPAG

Decrease

[116]

 

ELS mice

mPFC IL

Decrease

[117]

sIPSC

HFD + CSDS mice

mPFC

Decrease

[110]

 

CSDS mice

mPFC-LHb neurons

Decrease

[118]

 

CUMS mice

NAC

Decrease

[119]

 

CUMS mice

Prelimbic cortical

Decrease

[120]

 

SDPS rats

Hippocampus CA1

Decrease

[121]

mIPSC

CSDS mice

NAC

Decrease

[122]

 

long-term isolation mice

Intracentral amygdala

Decrease

[123]

 

CRS mice

Hippocampus

Decrease

[124]

 

CVS mice

mPFC

Increase

[125]

 

CRS mice

ACC

Decrease

[104]

 

CUS mice

mPFC PrL D1-PYR

Increase

[113]

 

MS rats

Hippocampus CA1 pyramidal cells

Increase

[126]

 

ELA mice

NAc medium spiny neurons

Decrease

[127]

 

RMS mice

Hippocampus CA1

Decrease

[128]

  1. sEPSC: spontaneous excitatory postsynaptic currents; mEPSC: miniature excitatory postsynaptic currents; sIPSC: spontaneous inhibitory postsynaptic currents; mIPSC: miniature inhibitory postsynaptic currents; RS: restraint stress; HFD + CSDS: high-fat diet + chronic social defeat stress; CVS: chronic variable stress; CIS: chronic immobilization stress; CUS:chronic unpredictable stress; ELS: early life stress; LH: learned helplessness; LANs: lights at night; CSDS: chronic social defeat stress; CUMS: chronic unpredictable mild stress; SDPS: social defeat-induced persistent stress; CRS: chronic restraint stress; MS: maternal separation stress; ELA: early life adversity; RMS: repeated maternal separation; DRN: dorsal raphe nucleus; PVN: paraventricular nucleus; mPFC: medial prefrontal cortex; PrL: prelimbic cortex; IL: infralimbic cortex;D1-PYR: dopamine D1-expressing pyramidal neurons; D2-PYR: dopamine D2-expressing pyramidal neurons; vlPAG: ventrolateral periaqueductal gray; NAc: nucleus accumbens; ACC: anterior cingulate cortex
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Cell & Bioscience

ISSN: 2045-3701

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