Table 1 Canonical and non-canonical functions of TERC in Immune Cell Regulation
From: Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex
Disease | Mechanism | Function Type | Reference |
|---|---|---|---|
Rheumatoid Arthritis | Cytokine regulation via NF-κB pathway. | Non-Canonical | [141] |
Multiple Sclerosis | Cytokine regulation via NF-κB pathway. | Non-Canonical | [141] |
Type II Diabetes | Cytokine regulation via NF-κB pathway. | Non-Canonical | [141] |
Dyskeratosis Congenita | Telomere shortening due to TERC mutations. | Canonical | [142] |
Aplastic Anemia | Impaired telomere maintenance in hematopoietic stem cells. | Canonical | [143] |
Idiopathic Pulmonary Fibrosis | Telomerase dysfunction in alveolar cells. | Canonical | [144] |
Cardiovascular Diseases | Telomere shortening in vascular cells (canonical); oxidative stress regulation (non-canonical). | Canonical & Non-Canonical | [145] |
Neurodegenerative Diseases | Telomere maintenance in neurons (canonical); mitochondrial and inflammatory regulation (non-canonical). | Canonical & Non-Canonical | [146] |