Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 6 | Cell & Bioscience

Fig. 6

From: Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression

Fig. 6

Hepatic metabolic gene profile during MASH-HCC disease progression in DIAMOND mice. NanoString nCounter mouse metabolic mRNA panel with a customized sphingolipid metabolic panel was used to profile the significant changes in key genes related to both hepatic lipid and sphingolipid metabolism in MASH-HCC progression. Liver RNA samples from each group (n = 3) were used. DEGs were identified in different groups using FC and p-values (FC ≥ 1.5 and p-value < 0.05). (A) Hierarchical clustering heatmaps display changes in sphingolipid metabolism-related genes between WDSW-6 M and CDNW-6M. (B) Volcano plots highlight major upregulated and downregulated genes in WDSW-6 M compared to the CDNW-6 M group. (C) Hierarchical clustering heatmaps display changes in sphingolipid metabolism-related genes between WDSW-1Y and CDNW-1Y. (D) Volcano plots highlight major upregulated and downregulated genes in WDSW-1Y compared to the CDNW-1Y group. Statistical significance relative to CDNW group: *p < 0.05, **p < 0.01, ***p < 0.001 (n = 3, male). DEG: Differentially Expressed Gene; FC: Fold Change

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us