Fig. 5

Ceramide composition and levels in the liver during MASH-HCC disease progression in DIAMOND mice. Liver tissues were processed for ceramide profiles using LC-MS/MS. (A) Pie charts showing the ceramide (Cer) composition profile in the liver from different groups expressed as a percentage of total Cer. (B) Levels of different types of Cers in the liver. Data are expressed as the mean ± SEM. Statistical significance relative to the corresponding CDNW group: *p < 0.05, ***p < 0.001. Statistical significance relative to CDNW-6 M or WDSW-6 M group: #p < 0.05, ##p < 0.01 (n = 10–15)