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Fig. 4 | Cell & Bioscience

Fig. 4

From: Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures

Fig. 4

Cancer-specific eccEnhancers contribute to cancer development and poor outcomes. A The different eccEnhancers in the cancer group (C) and the noncancer group (NC). B KEGG pathway enrichment of the closest active genes regulated by super-enhancers carried by cancer-specific eccEnhancers. C The target genes are regulated by multiple (≥ 3) super-enhancers carried by cancer-specific eccEnhancers. D Expression levels of IFNGR2 in the CHOL, COAD, LIHC, and PAAD cohorts from the TCGA database. *P < 0.05. E Overall survival analysis according to IFNGR2 and C8ORF37 expression levels in cancer cohorts associated with malignant biliary strictures from the TCGA database, including CHOL, COAD, LIHC, and PAAD cohorts. PAAD pancreatic adenocarcinoma, CHOL cholangiocarcinoma, COAD colon adenocarcinoma, LIHC liver hepatocellular carcinoma

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Cell & Bioscience

ISSN: 2045-3701

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