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Fig. 7 | Cell & Bioscience

Fig. 7

From: KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer

Fig. 7

SEPP1 regulates CD8+ T cell-mediated immune responses via MDSCs. KPC and Pan02 cells (5 × 105 cells) were injected into the flank of C57BL/6 mice subcutaneously. (A) Representative photos of xenograft tumors and tumor volumes in normal mouse xenograft model. (B) The protein level of SEPP1 was detected by western blot. (C) The serum level of SEPP1 in mice was detected by ELISA assay. (D) The immunoreactivity of Ki-67 was detected by IHC analysis. (E) The proportion of MDSCs was detected by flow cytometry. (F) The expression of LRP8 in MDSCs was analyzed by flow cytometry. (G) The proportion of CD8+ T cells and IFN-γ expression were detected by flow cytometry. **, P < 0.01; ***, P < 0.001. n = 5

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Cell & Bioscience

ISSN: 2045-3701

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