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Fig. 2 | Cell & Bioscience

Fig. 2

From: KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer

Fig. 2

SEPP1 regulates immune escape of PC cells via modulating CD8+ T cell abundance. Pan02 cells (5 × 105 cells) were injected into the flank of C57BL/6 mice subcutaneously. (A) Representative photos of xenograft tumors and tumor volumes. (B) The immunoreactivity of SEPP1 in xenograft tumors was assessed by IHC analysis. Pan02 cells (1 × 106 cells) were injected into the tail vein of C57BL/6 mice. (C) The tumor growth and metastasis were monitored by in vivo bioluminescence imaging. (D) Representative photos and H&E staining of liver tissues. (E) The proportions of CD4 + T cells, CD8+ T cells, MDSCs and macrophages were detected by flow cytometry. **, P < 0.01; ***, P < 0.001. n = 5

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Cell & Bioscience

ISSN: 2045-3701

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