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Fig. 9 | Cell & Bioscience

Fig. 9

From: CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury

Fig. 9

The mechanism diagram demonstrates that circtm2b exacerbates mitochondrial oxidative stress and causes sleep disorders. The mechanism diagram was plotted by Figdraw and Biorender. TBI or H2O2 intervention leads to upregulation of circItm2b, mitochondrial dysfunction, and oxidative stress. The increased circItm2b binding the Sirt1, which increased the Nox4 expression. The upregulated Nox4 aggravates mitochondrial oxidative stress. Mitochondrial dysfunction and losses of Clock and Bmal1 disrupt the circadian rhythm in the suprachiasmatic nucleus of the hypothalamus. CircItm2b is used as a new target for sleep disorders after TBI

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