Table 1 Association between TOPBP1 expression and clinicopathological features of patients with PDAC using the TCGA database
Characteristics | Variable | Total | TOPBP1 | p value | |
|---|---|---|---|---|---|
(n = 179) | Low expression | High expression | |||
Age (years) | < 65 | 94 (52.5%) | 47 (26.3%) | 47 (26.3%) | 0.937 |
≥ 65 | 85 (47.5%) | 42 (23.5%) | 43 (24.0%) | ||
Sex | Female | 80 (44.7%) | 40 (22.3%) | 40 (22.3%) | 0.946 |
Male | 99 (55.3%) | 49 (27.4%) | 50 (27.9%) | ||
Pathologic stage | Stage I | 21 (11.7%) | 11 (6.2%) | 10 (5.7%) | 0.674 |
Stage II | 147 (82.1%) | 70 (39.8%) | 77 (43.8%) | ||
Stage III & IV | 8 (4.5%) | 5 (2.8%) | 3 (1.7%) | ||
Histologic grade | G1 & G2 | 127 (70.9%) | 72 (40.7%) | 55 (31.1%) | 0.003* |
G3 & G4 | 50 (27.9%) | 16 (9.0%) | 34 (19.2%) | ||
Primary therapy outcome | PD | 50 (27.9%) | 15 (10.7%) | 35 (25.0%) | 0.016* |
SD & PR & CR | 90 (50.3%) | 46 (32.9%) | 44 (31.4%) | ||
OS event | Alive | 86 (48.0%) | 53 (29.6%) | 33 (18.4%) | 0.002* |
Dead | 93 (52.0%) | 36 (20.1%) | 57 (31.8%) | ||