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Fig. 10 | Cell & Bioscience

Fig. 10

From: Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice

Fig. 10

MCU knockdown inhibits the Hippo/YAP signaling and restores AMPK inactivation during MASH development. A Western blots for p-MOB1, MOB1, p-LATS1/2, LATS1/2, p-AMPK/AMPK, p-YAP and YAP in MCU silencing AML12 hepatocytes with OPA or vehicle treatment for 24 h; and β-actin as loading control. B Densitometric analyses of blots for p-LATS/LATS, p-MOB1/MOB1, p-AMPK/AMPK, and p-YAP/YAP. C Representative images of ORO staining in AML12 hepatocytes from indicated treatment. Scale bar: 100 μm. D Western blots for p-MOB1, MOB1, p-LATS1/2, LATS1/2, p-YAP and YAP in AML12 hepatocytes; and β-actin as loading control. E Densitometric analyses of blots for p-LATS/LATS, p-MOB1/MOB1, and p-YAP/YAP. All data are presented as the mean ± SD. P-value are for two-way ANOVA with Tukey’s test. *P < 0.05, **P < 0.01, and ***P < 0.001; ns indicates not significant

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Cell & Bioscience

ISSN: 2045-3701

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