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Table 1 Small molecules that target the golgi for tumor inhibition

From: Golgiphagy: a novel selective autophagy to the fore

Drug

Mechanism

Tumor type

References

Brefeldin A

Inhibition of GBF1 and BIGs

colorectal cancer, prostatic cancer, adenoid cystic carcinoma

[18, 121, 132, 133]

AMF-26/M-COPA

Inhibition of GBF1

breast cancer

[134]

Golgicide A

Inhibition of GBF1

breast cancer

[135, 136]

Swainsonine

Inhibition of Golgi mannosidase II

gastric cancer,

glioma

[122, 123, 137]

Mannotatin A

Inhibition of Golgi mannosidase II

Melanoma

[138, 139]

IN-9

Inhibition of PI4KIIIβ

lung cancer

[140, 1]

LM11

Inhibition of ARF1 activation through targeting the ARF1-GDP/ARNO complex

breast cancer

[142, 143]