Fig. 4

The expression of enteroendocrine-specific hormone and transcription factors are upregulated in PRMT1^indΔIEC small intestinal epithelium. A The expression of up-regulated enteroendocrine markers (transcriptional factors, EEC-specific hormones and granule components) were obtained from the RNA-seq data and the fold change between PRMT1^indΔIEC (KO)_d14 and PRMT1^fl/fl (WT)_d14 small intestinal crypts were presented with P-adj values in the table. B, C RT-PCR validation of the expression of intestinal EEC hormone genes (B) and EEC transcription factors (C) in the small intestinal epithelial cells of PRMT1^indΔIEC and PRMT1^fl/fl mice at day 14 after the first tamoxifen injection. The values were presented as mean ± SEM with n = 5 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001. GC, granule components