Fig. 2

Differentially expressed genes (DEGs) after inducible PRMT1 KO in adult small intestinal crypts. A, B DEG analysis of the small intestinal crypts of adult PRMT1^fl/fl (WT) and PRMT1^indΔIEC (KO) mice at day 7 (A) and day 14 (B) after the initiation of tamoxifen treatment as in Fig. 1. MA plot visualizing the log2-fold change (M values) differences according to log2-mean expression levels (A values). Red and blue dots represent significantly (Adjusted p-value < 0.05) up- and down-regulated genes, respectively, in the KO compared to PRMT1^fl/fl intestine. Note that there were many more DEGs at day 7 compared to day 14, with 1733 up-regulated and 2282 down-regulated genes in at day 7 vs 943 up-regulated and 1171 down-regulated genes at day 14. C, D Venn diagrams depicting overlaps between DEGs after 7 and 14 days of tamoxifen treatment for the up- (C) or down- (D) regulated DEGs, respectively. Note that most of the upregulated (C) or downregulated (D) DEGs at day 14 were similarly regulated on day 7. WT: PRMT1^fl/fl, KO: PRMT1^indΔIEC