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Fig. 5 | Cell & Bioscience

Fig. 5

From: A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease

Fig. 5

t-SNE analysis of the CD8+ T-cell subset with PD-1. A t-SNE maps of all subjects demonstrating the numerical values of FSC-H, SSC-H, CD8, and PD-1 expression levels. B Pseudocolor smooth density plots displaying the change in the CD8+ T-cell population frequency with a selected marker, PD-1, among healthy volunteers, mild AD patients, and moderate AD patients. C Eight populations on the t-SNE map were clustered by the FlowSOM algorithm. D The heatmap demonstrates the frequency of each population with different markers (FSC, SSC, CD8, and PD-1). E Populations 3 and 7 in CD8+ T cells among healthy volunteers, mild AD patients, and moderate AD patients are shown in the scatter plots. A Mann‒Whitney U test was used to compare healthy volunteers (n = 16), mild AD patients (n = 10), and moderate AD patients (n = 6); median values are indicated by thick black lines in the scatter plots. *p < 0.05

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Cell & Bioscience

ISSN: 2045-3701

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