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Fig. 5 | Cell & Bioscience

Fig. 5

From: Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy

Fig. 5

Inhibition of autophagy restored CRPC cell sensitivity to docetaxel. a PC3 cells (1 × 104/well) were co-cultured with MSCs in an existence of DTX (20 μM). The occurrence of autophagy was inhibited by autophagy inhibitor CQ (10 μM) or 3-MA (2 mM). CCK8 assay was used to examined the cell viability of PC3 cells. b The cell apoptosis of PC3 cells was analyzed by flow cytometry using Annexin V-FITC/PI. c CCK8 assay was used to examined the cell viability of DU145 cells. d The cell apoptosis of DU145 cells was analyzed by flow cytometry using Annexin V-FITC/PI. *P < 0.05; **P < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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