Fig. 3
From: Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells
NO donor can reinstall the expression of PD-L1 on MSCs. a, b WT MSCs were treated by IFNγ, TNFα and IL-17 with or without SMT and SNAP (1 mM). The expression of PD-L1 mRNA and protein was then measured after 24 h and 48 h, respectively. c The statistical results of three separate experiments described in B are also showed. d, e iNOS−/− MSCs were stimulated by cytokines in the presence or absence of SNAP. The expression of PD-L1 mRNA and protein was then measured after 24 h and 48 h, respectively. f The statistical results of three separate experiments described in e are also showed. g, h WT MSCs were treated with indicated combinations of cytokines. After 24 h and 48 h, the expression of PD-L1 mRNA and protein was then measured, respectively. i The statistical results of three separate experiments described in h are also showed