Fig. 1
From: Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain?
Brain-specific metabolic TME may contribute to immunotherapy efficacy. In the mammalian CNS, mitochondrion-dependent oxidative phosphorylation (OXPHOS) is a favorable mechanism of cellular metabolism. Examination of clinical specimens suggests an immunosuppressive TME in the brain with fewer T cell infiltration, which is dependent on OXPHOS for effector functions, and elevated levels of OXPHOS activities in brain metastases. This highlights a prominent example where brain specific TME metabolic environment may contribute to therapeutic response