Fig. 5

HDR based genome editing applications. a Gene replacement is applicable for basic research and agriculture. b HDR can add a tag to a protein for easy purification and study. c Fluorescent proteins such as green fluorescent protein (GFP) can be fused to a gene of interest for in vivo study. d Gene stacking is useful for placing genes physically close together on a chromosome. This is accomplished by creating a target site for HDR at the end of each gene, which allows for modular addition of genes